Opportunity Information: Apply for RFA AG 22 001
The grant opportunity "Limited Competition: National Institute on Aging (NIA) Late Onset of Alzheimers Disease (LOAD) Family-Based Study (FBS) (U24 Clinical Trial Not Allowed)" (Funding Opportunity Number RFA-AG-22-001) is a National Institutes of Health (NIH) cooperative agreement designed to strengthen and extend the infrastructure behind a major genetics resource focused on late-onset Alzheimer disease and related dementias. It sits within the Department of Health and Human Services under NIH, and it is tied closely to the Alzheimers Disease Sequencing Project (ADSP), a large, coordinated effort that uses genomic sequencing to discover genetic variants that influence risk for Alzheimer disease and Alzheimer disease-related dementias (AD/ADRD). Rather than funding a typical hypothesis-driven research project, this announcement is focused on building and operating the practical systems needed to keep a family-based cohort productive and expanding over time.
The core purpose is to support the collection and management of high-value family-based data and biospecimens from families in which multiple relatives are affected by Alzheimer disease and related dementias. These multiply affected families are especially valuable for genetic discovery because patterns of disease across relatives can help researchers identify inherited risk factors, interpret rare variants, and refine signals that might be harder to detect in unrelated case-control datasets. The FOA emphasizes expanding the existing NIA Late Onset of AD Family Based Study sample set, meaning the funded group is expected to add more informative relatives and deepen the overall dataset rather than starting from scratch.
A central feature of the work is infrastructure for data collection and longitudinal follow-up. That includes maintaining the operational capability to contact and re-contact participants, track outcomes over time, and update clinical and cognitive information as participants age and as new diagnoses or changes in status occur. Longitudinal follow-up matters here because Alzheimer disease develops over many years, and repeated measurements can help distinguish early signals, progression patterns, and differences between Alzheimer disease and other dementia syndromes. The FOA also calls out ascertainment of antecedent risk factors, which generally refers to capturing exposures and characteristics that occur before dementia onset and may influence risk or resilience, such as medical history, cardiovascular and metabolic factors, lifestyle variables, and other relevant background information. Collecting these kinds of data strengthens the ability of the broader ADSP community to study gene-environment interplay and to interpret genetic findings in a richer clinical context.
Another explicit objective is the characterization of additional relatives from the multiply affected families. In practical terms, that means identifying and enrolling more family members beyond the original participants, gathering pedigree information, documenting affected and unaffected status, and ensuring that the accompanying phenotypic information is detailed enough to be useful for genetic analyses. Adding unaffected relatives can be just as important as adding affected relatives, because unaffected older individuals in high-risk families may help identify protective factors and improve segregation analyses within pedigrees. The overall expectation is that these efforts will enhance the quality, completeness, and analytic value of the family-based resource that feeds into ADSP sequencing and downstream analyses.
Mechanistically, this is a cooperative agreement (U24), which typically means there is substantial NIH programmatic involvement in guiding priorities, coordinating activities, and ensuring that the infrastructure aligns with broader program goals and data standards. The title also states "Clinical Trial Not Allowed," signaling that the award is not intended to support interventional clinical trial activities; the scope is infrastructure and observational follow-up rather than testing treatments or assigning interventions.
This was a limited competition opportunity, meaning it was restricted to a defined set of eligible applicants described in the full announcement (the listing notes "Others" with clarification in the eligibility text). The program fell under the health activity category and a CFDA listing of 93.866. The FOA was created on December 14, 2020, with an original closing date of February 17, 2021. NIH anticipated making one award, with an award ceiling of $2,400,000, indicating a single, relatively substantial infrastructure award intended to support a coordinated national resource rather than multiple small independent projects.
In summary, RFA-AG-22-001 was aimed at sustaining and expanding the operational backbone for the NIA late-onset Alzheimer family-based cohort that supports the ADSP. The funded effort would be expected to keep the cohort engaged over time, broaden participation within informative families, collect and update high-quality clinical and risk factor data, and ensure that these expanded family resources are positioned to accelerate genetic discovery and related analyses across the Alzheimer research community.Apply for RFA AG 22 001
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: National Institute on Aging (NIA) Late Onset of Alzheimers Disease (LOAD) Family-Based Study (FBS) (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on Dec 14, 2020.
- Applicants must submit their applications by Feb 17, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,400,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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