Opportunity Information: Apply for RFA CA 20 033
The SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44, Clinical Trial Optional) is a National Institutes of Health funding opportunity from the National Cancer Institute (NCI) designed to help small businesses push promising, cancer-relevant technologies out of the Phase II research stage and into real-world commercialization. It specifically targets projects that have already been supported through an SBIR or STTR Phase II award (from any federal agency, not just NIH) and now need additional resources to complete the next, often more expensive steps required to reach the market. In practical terms, this FOA is about closing the gap between a proven Phase II outcome (like a validated prototype or strong early performance data) and the kind of product readiness investors, partners, regulators, and customers expect.
A central feature of this program is the "bridge" concept: NCI funding is meant to be matched or exceeded by outside, independent third-party support. The FOA strongly emphasizes partnerships with third-party investors and/or strategic partners (for example, venture capital, angel investors, corporate partners, foundations, or other non-federal sources) to share risk and accelerate development. Applicants are required to submit a detailed Commercialization Plan that lays out the path to market and clearly describes third-party funding that has already been secured or that is expected during the Phase IIB project period. The expectation is that the amount of independent third-party funding will be equal to or greater than the total NCI funds requested over the life of the Phase IIB Bridge Award, signaling that the project has credible market pull and external validation.
The scope of work supported under this FOA can cover both preclinical and clinical stages of development, depending on what is needed to reach commercialization for the specific technology. That can include late-stage product development activities, refinement and scale-up, validation studies, regulatory preparation, and other milestones that typically sit between academic-style R&D and a commercial launch. Clinical trials are allowed but not required, meaning a company can propose clinical trial activities if they are appropriate for the technology and commercialization pathway, but the program is not limited only to clinical trial proposals. This makes the opportunity relevant across a wide range of cancer technologies, including but not limited to therapeutics, diagnostics, devices, imaging tools, software-enabled solutions, and platform technologies, as long as they are cancer-relevant and ready for the next major commercialization step.
Eligibility is limited to small business concerns applying under the SBIR mechanism, consistent with the program's purpose of advancing small-business-led innovation. Non-U.S. (non-domestic) entities and foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible. However, the FOA notes that certain "foreign components" may be allowable under NIH policy definitions and rules, so applicants with international collaborations or subcontracting needs would have to check the specific NIH Grants Policy Statement guidance and the FOA's eligibility details to determine what is permitted.
Administratively, this is a discretionary grant opportunity in the health area (CFDA numbers 93.394 and 93.395) with the funding opportunity number RFA-CA-20-033 and an original closing date of 2020-08-31. Overall, the program is structured to reward companies that have already demonstrated Phase II progress and can show a credible, investor-aligned plan to cross the expensive and operationally demanding stretch between technical feasibility and commercial readiness, with NCI funding acting as leverage alongside substantial third-party investment.Apply for RFA CA 20 033
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
- This funding opportunity was created on 2020-03-06.
- Applicants must submit their applications by 2020-08-31. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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| Core Infrastructure Support for Cancer Epidemiology Cohorts (U01 Clinical Trial Not Allowed) Apply for PAR 20 136 Funding Number: PAR 20 136 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed) Apply for PAR 20 131 Funding Number: PAR 20 131 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Research to Reduce Morbidity and Improve Care for Pediatric, and Adolescent and Young Adult (AYA) Cancer Survivors (R01 Clinical Trial Optional) Apply for RFA CA 20 027 Funding Number: RFA CA 20 027 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Research to Reduce Morbidity and Improve Care for Pediatric, and Adolescent and Young Adult (AYA) Cancer Survivors (R21 Clinical Trial Optional) Apply for RFA CA 20 028 Funding Number: RFA CA 20 028 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| NIDA Small Research Grant Program (R03 Clinical Trial Required) Apply for PA 20 146 Funding Number: PA 20 146 Agency: National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| Extracellular RNA carrier subclasses in processes relevant to Substance Use Disorders or HIV infection (R21- Clinical Trial Not Allowed) Apply for PAR 20 148 Funding Number: PAR 20 148 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Exploiting in vivo or in situ imaging approaches to understand HIV-relevant processes in the context of substance use disorders (R61/R33 Clinical Trials Optional) Apply for RFA DA 21 005 Funding Number: RFA DA 21 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Extracellular RNA carrier subclasses in processes relevant to Substance Use Disorders or HIV infection (R01- Clinical Trial Not Allowed) Apply for PAR 20 147 Funding Number: PAR 20 147 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Academic-Industrial Partnerships (AIP) to Translate and Validate In Vivo Imaging Systems (R01 Clinical Trial Optional) Apply for PAR 20 155 Funding Number: PAR 20 155 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Addressing Racial Disparities in Maternal Mortality and Morbidity (R01 Clinical Trial Optional) Apply for RFA MD 20 008 Funding Number: RFA MD 20 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Reducing Stigma Related to Drug Use in Human Service Settings (R34 Clinical Trial Required) Apply for RFA DA 21 001 Funding Number: RFA DA 21 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: $225,000 |
| Reducing Stigma Related to Drug Use in Human Service Settings (R21 Clinical Trial Optional) Apply for RFA DA 21 002 Funding Number: RFA DA 21 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| New Informatics Tools and Methods to Enhance U.S. Cancer Surveillance Research (U01 Clinical Trial Optional) Apply for PAR 20 170 Funding Number: PAR 20 170 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Long-Term Effects of Disasters on Health Care Systems Serving Health Disparity Populations (R01- Clinical Trial Optional) Apply for PA 20 172 Funding Number: PA 20 172 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Identifying Innovative Mechanisms or Interventions that Target Multimorbidity and Its Consequences (R01 Clinical Trial Optional) Apply for PAR 20 180 Funding Number: PAR 20 180 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advancing Research to Develop Improved Measures and Methods for Understanding Multimorbidity (R01 Clinical Trial Optional) Apply for PAR 20 179 Funding Number: PAR 20 179 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Research Project Grant (Parent R01 Clinical Trial Required) Apply for PA 20 183 Funding Number: PA 20 183 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Large scale mapping and/or molecular profiling of ensembles and/or cell-types mediating opioid action in the rodent brain (R01 - Clinical Trial Not Allowed) Apply for PAR 20 182 Funding Number: PAR 20 182 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) Apply for PA 20 190 Funding Number: PA 20 190 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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