Opportunity Information: Apply for PA 19 095
The Emotion Regulation, Aging and Mental Disorder (R21 Clinical Trial Not Allowed) opportunity (PA-19-095) is a National Institutes of Health discretionary grant announcement focused on early-stage, mechanistic research that explains how emotion regulation changes with age and how those changes may contribute to mental disorders in middle-aged and older adults. The central aim is not to test a treatment in a clinical trial, but to dig into underlying mechanisms, especially the combined (integrative) neural and behavioral processes that support emotion regulation and how those processes may become irregular in mood and anxiety disorders as adults age.
A major emphasis of the announcement is understanding whether emotion regulation problems in older adults reflect departures from typical developmental trajectories of emotion processing. Many older adults show patterns of improved emotional functioning with age (for example, shifts in attention, appraisal, and coping that can support greater emotional stability). This FOA encourages research that asks whether older adults who experience affective dysregulation (such as episodes of depression, anxiety, or related mood instability) still show those age-associated improvements, or whether their brain-behavior emotion regulation systems follow atypical maturational paths. By comparing typical versus atypical trajectories, applicants are expected to clarify what is "off track" in late-life mood and anxiety disorders and how those irregularities manifest at both neural and behavioral levels.
The practical value NIH is looking for is clear: studies supported under this FOA should be positioned to reveal new, mechanism-based targets for prevention or intervention, or to indicate how existing intervention approaches might be better matched to a person s stage of adulthood. In other words, the work should generate clues about how to normalize emotion dysregulation or strengthen emotional resilience across the adult life course, even if the project itself is not running a clinical trial. Mechanistic findings could inform later intervention development, help identify biomarkers or risk indicators, or improve understanding of when and for whom particular strategies are likely to work.
This is an R21 mechanism, which generally supports exploratory, developmental projects that can test bold ideas, pilot novel approaches, or establish feasibility for larger future studies. The announcement is categorized under health research (CFDA 93.242) and is issued by NIH. The listed original closing date in the provided record is 2022-01-07, and no award ceiling or expected number of awards is specified in the excerpt.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses) and small businesses; and other entities. The FOA also explicitly highlights additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations).Apply for PA 19 095
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Emotion Regulation, Aging and Mental Disorder (R21 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
- This funding opportunity was created on 2018-11-29.
- Applicants must submit their applications by 2022-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the title and number of this funding opportunity?
This opportunity is titled Emotion Regulation, Aging and Mental Disorder (R21 Clinical Trial Not Allowed) and is identified as PA-19-095.
Which agency is offering this grant?
The opportunity is issued by the National Institutes of Health (NIH) as a discretionary grant announcement.
What kind of research is this FOA trying to support?
The focus is on early-stage, mechanistic research that explains how emotion regulation changes with age and how those changes may contribute to mental disorders in middle-aged and older adults. The emphasis is on understanding underlying mechanisms, especially the integrated neural and behavioral processes that support emotion regulation and how these processes may become irregular in mood and anxiety disorders as adults age.
Is a clinical trial allowed under this opportunity?
No. The opportunity is explicitly labeled "Clinical Trial Not Allowed". The central aim is not to test a treatment in a clinical trial, but to study mechanisms underlying emotion regulation and aging.
What age groups does the research need to address?
The FOA targets research relevant to middle-aged and older adults, with a strong emphasis on aging-related changes in emotion regulation.
Which mental health conditions are emphasized?
The announcement highlights mood and anxiety disorders, and more broadly refers to affective dysregulation such as episodes of depression, anxiety, or related mood instability in aging adults.
What is the main scientific question NIH wants applicants to address?
A major emphasis is understanding whether emotion regulation problems in older adults represent departures from typical developmental trajectories of emotion processing. Applicants are encouraged to compare typical versus atypical trajectories to clarify what is "off track" in late-life mood and anxiety disorders and how irregularities appear at both neural and behavioral levels.
What does the FOA mean by "typical" age-associated emotional changes?
In the information provided, typical age-associated changes include patterns of improved emotional functioning with age, such as shifts in attention, appraisal, and coping that can support greater emotional stability.
What kinds of mechanisms are especially encouraged?
The FOA places special emphasis on combined (integrative) neural and behavioral processes supporting emotion regulation, and how those processes may become irregular in mood and anxiety disorders as adults age.
What outcomes or value does NIH want from mechanistic studies funded under this FOA?
NIH is looking for studies positioned to reveal new, mechanism-based targets for prevention or intervention, or to indicate how existing intervention approaches might be better matched to a person’s stage of adulthood. While the project itself is not running a clinical trial, mechanistic findings are expected to generate actionable clues that could inform later intervention development.
Does the FOA expect projects to directly develop or test interventions?
Based on the provided description, the central aim is mechanistic understanding, not intervention testing in a clinical trial. However, the work should be positioned to inform future efforts by identifying targets, biomarkers, risk indicators, or insights about when and for whom strategies may work.
What is the funding mechanism (grant type)?
This opportunity uses the R21 mechanism, which generally supports exploratory and developmental projects.
What is an R21 intended for in this context?
As described, an R21 generally supports projects that can test bold ideas, pilot novel approaches, or establish feasibility for larger future studies.
What is the CFDA number and category listed for this opportunity?
The announcement is categorized under health research with CFDA 93.242.
When was the original closing date listed in the provided record?
The provided record lists an original closing date of 2022-01-07.
Is there an award ceiling specified?
No award ceiling is specified in the excerpt provided.
Is the expected number of awards provided?
No. The excerpt does not specify the expected number of awards.
Who is eligible to apply?
Eligibility is broad and includes many U.S. and non-U.S. organizations. Eligible applicants include:
- State, county, city, township, and special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Tribal organizations that are not federally recognized
- Public housing authorities and Indian housing authorities
- Nonprofits with or without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations (other than small businesses) and small businesses
- Other entities
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA explicitly includes non-domestic (non-U.S.) entities (foreign organizations) among eligible applicants.
Are U.S. territories or possessions eligible?
Yes. The FOA explicitly highlights U.S. territories or possessions as eligible.
Are minority-serving institutions specifically called out as eligible?
Yes. The FOA explicitly highlights several categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly highlights faith-based or community-based organizations as eligible applicants.
Are federal agencies allowed to apply?
Yes. The FOA highlights eligible federal agencies as eligible applicants.
What does the FOA encourage researchers to compare?
It encourages comparing typical versus atypical trajectories of emotion regulation and emotion processing across adulthood, to identify how late-life mood and anxiety disorders may differ from expected developmental patterns.
What does NIH mean by being "positioned to reveal" targets if clinical trials are not allowed?
In the provided description, this means mechanistic studies should generate evidence that could later support prevention or intervention efforts, such as identifying mechanism-based targets, biomarkers, or risk indicators, or clarifying how to match approaches to a person’s stage of adulthood, without directly running a clinical trial under this FOA.
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