Opportunity Information: Apply for HT9425 23 CPMRP IIRA
The DOD Chronic Pain Management, Investigator-Initiated Research Award (IIRA) is a Department of Defense funding opportunity administered by the U.S. Army Medical Research Acquisition Activity (USAMRAA) to support investigator-driven research aimed at meaningfully improving chronic pain care. The core purpose of this mechanism is to back studies with strong potential to produce significant advances in research knowledge, clinical care, and/or quality of life outcomes that align with the program's FY23 IIRA Focus Areas. It is positioned as a science and technology research and development award (CFDA 12.420) and is intended to encourage impactful, well-justified projects rather than incremental work.
The program is designed to be broad in scientific approach, allowing basic, translational, and clinically oriented research. Applicants may propose studies using animal models, human anatomical substances, or human subjects, and the opportunity also allows correlative work linked to an already ongoing clinical trial. A key boundary is that this award cannot be used to conduct a clinical trial itself; in other words, it supports research that can inform or leverage clinical trials, but it does not fund the execution of a new clinical trial under this mechanism. The solicitation also emphasizes the value of multidisciplinary teams and innovative approaches, signaling that proposals bringing together multiple fields (for example, pain medicine, rehabilitation, neuroscience, psychology, biomedical engineering, or data science) and proposing creative methods are particularly welcome.
There is a clear restriction related to opioids: projects that aim to develop new or novel opioid-based therapeutic interventions are considered outside the intent of the award and will not be funded. At the same time, the program does permit opioid-related research when the goal is to understand, improve, or reduce opioid utilization in chronic pain management within the reality of current prescribing practices. That means studies focused on safer pain management strategies, prescribing optimization, risk reduction, tapering support, non-opioid alternatives, or systems-level interventions to reduce reliance on opioids can be considered appropriate, as long as they fit within the broader focus areas and do not center on creating new opioid therapies.
From an administrative standpoint, the opportunity number is HT9425 23 CPMRP IIRA. The funding instrument types listed are grants and cooperative agreements, which generally indicates that some awards may involve more direct government involvement or coordination depending on the project needs and structure. Eligibility is described as unrestricted, meaning the competition is open to a wide range of applicant entity types, subject to any additional eligibility details that may appear in the full announcement. The posting date is July 3, 2023, with an original closing date of November 9, 2023. The expected number of awards is six. The award ceiling is listed as 0, which typically indicates that a specific maximum dollar cap is not provided in the summarized metadata and applicants should rely on the full funding announcement for budget expectations and constraints.
Overall, this award supports investigator-initiated chronic pain research that can realistically move the field forward, encourages cross-disciplinary and innovative work, allows studies involving humans and human materials (and correlative studies tied to existing trials), prohibits using the mechanism to run clinical trials, and draws a firm line against developing new opioid-based treatments while still allowing research aimed at reducing opioid use and improving prescribing-related outcomes.Apply for HT9425 23 CPMRP IIRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Chronic Pain Management, Investigator-Initiated Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jul 03, 2023.
- Applicants must submit their applications by Nov 09, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DOD Chronic Pain Management, Investigator-Initiated Research Award (IIRA)
What is the DOD Chronic Pain Management, Investigator-Initiated Research Award (IIRA)?
The DOD Chronic Pain Management, Investigator-Initiated Research Award (IIRA) is a Department of Defense funding opportunity administered by the U.S. Army Medical Research Acquisition Activity (USAMRAA). It supports investigator-driven research intended to meaningfully improve chronic pain care and produce significant advances in research knowledge, clinical care, and/or quality of life outcomes aligned with the program's FY23 IIRA Focus Areas.
What is the main purpose of this award mechanism?
The core purpose is to back impactful, well-justified chronic pain research with strong potential to move the field forward. The opportunity is positioned to support significant advances rather than incremental work.
What kinds of research approaches are allowed under this opportunity?
The program is broad in scientific approach and allows basic, translational, and clinically oriented research. Proposals may include studies using animal models, human anatomical substances, or human subjects.
Does this award allow research involving human subjects?
Yes. The opportunity allows studies involving human subjects, as well as research involving human anatomical substances.
Can applicants propose animal model studies?
Yes. The opportunity allows studies using animal models.
Can this award be used to conduct a clinical trial?
No. A key restriction is that this award cannot be used to conduct a clinical trial. The mechanism supports research that can inform clinical trials or leverage clinical trial contexts, but it does not fund the execution of a new clinical trial under this award.
If clinical trials are not allowed, what clinical-trial-related work is permitted?
Correlative work linked to an already ongoing clinical trial is permitted. In other words, the award can support research that connects to an existing trial (for example, associated analyses), but it cannot fund running the clinical trial itself.
Is multidisciplinary research encouraged?
Yes. The solicitation emphasizes multidisciplinary teams and innovative approaches. Projects that bring together multiple fields (for example, pain medicine, rehabilitation, neuroscience, psychology, biomedical engineering, or data science) are explicitly highlighted as especially welcome.
Is innovation explicitly valued in this program?
Yes. The opportunity signals that innovative and creative methods are particularly welcome, alongside a strong expectation that projects be impactful rather than incremental.
Are projects developing new opioid-based therapies eligible for funding?
No. Projects that aim to develop new or novel opioid-based therapeutic interventions are outside the intent of the award and will not be funded.
Is any opioid-related research allowed under this award?
Yes. Opioid-related research is allowed when the goal is to understand, improve, or reduce opioid utilization in chronic pain management within current prescribing realities. Examples described as potentially appropriate include research on safer pain management strategies, prescribing optimization, risk reduction, tapering support, non-opioid alternatives, or systems-level interventions to reduce reliance on opioids, provided they fit within the broader focus areas and do not center on creating new opioid therapies.
What are the FY23 IIRA Focus Areas?
The opportunity states that proposed work should align with the program's FY23 IIRA Focus Areas, but the specific focus areas are not listed in the provided summary. Applicants should rely on the full funding announcement for the complete list and definitions.
What is the opportunity number for this funding announcement?
The opportunity number is HT9425 23 CPMRP IIRA.
Who administers this opportunity?
It is administered by the U.S. Army Medical Research Acquisition Activity (USAMRAA) on behalf of the Department of Defense.
What funding instrument types are available?
The funding instrument types listed are grants and cooperative agreements. This indicates some awards may involve more direct government involvement or coordination depending on project needs and structure.
What is the CFDA listing for this program?
The award is positioned as a science and technology research and development award under CFDA 12.420.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning the competition is open to a wide range of applicant entity types, subject to any additional eligibility details that may appear in the full announcement.
When was the opportunity posted, and what was the closing date?
The posting date is July 3, 2023. The original closing date is November 9, 2023.
How many awards are expected to be made?
The expected number of awards is six.
Is there a maximum award amount (ceiling)?
The award ceiling is listed as 0 in the summarized metadata, which typically indicates a specific maximum dollar cap is not provided in that summary. Budget expectations and constraints should be confirmed in the full funding announcement.
What types of outcomes is the program trying to improve?
The program is aimed at meaningful improvements in chronic pain care and supports work with strong potential to produce significant advances in research knowledge, clinical care, and/or quality of life outcomes.
Is incremental research considered responsive to this mechanism?
The opportunity is intended to encourage impactful, well-justified projects rather than incremental work, indicating that proposals should clearly justify how they will move the field forward in a meaningful way.
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