Opportunity Information: Apply for PAR 22 138
Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R21-Clinical Trial Not Allowed) is a National Institutes of Health (NIH) grant opportunity (Funding Opportunity Number PAR 22-138) that supports exploratory, early-stage research using existing ABCD Study data rather than collecting new data or running interventions. The ABCD Study is a large, long-running national research effort that has been following children beginning at ages 9 to 10 and repeatedly assessing them over a 10-year period. Because the dataset spans a major developmental window from late childhood through adolescence, it allows researchers to examine how health, behavior, environment, and brain development change over time and how these factors relate to one another.
The core purpose of the announcement is to encourage investigators to analyze the publicly available ABCD dataset to produce new knowledge about adolescent health and development. The FOA emphasizes rapid acceleration of child and adolescent health research by leveraging data that have already been collected, curated, and shared with the broader scientific community through the NIMH Data Archive. In practical terms, applicants are expected to propose rigorous secondary analyses that can answer important questions about youth outcomes without needing to recruit participants, administer new measures, or conduct clinical trials.
ABCD data are broad and multidimensional, which is central to why NIH is promoting its use. The study includes measures across physical health and mental health, cognitive functioning and academic-related processes, substance use and risk behaviors, cultural and environmental influences, and detailed neuroimaging data capturing brain structure and function. This makes the opportunity well-suited for projects that integrate multiple domains, such as examining how social context and environmental exposures relate to mental health trajectories, how cognitive development intersects with substance use initiation, or how brain development patterns may predict later emotional or behavioral outcomes. Since ABCD is longitudinal, applicants can also focus on developmental change and timing, identifying early predictors of later outcomes and testing developmental models across repeated waves of data.
The mechanism is an NIH R21, which is typically used for exploratory or developmental research that can break new ground, test novel analytic approaches, or generate preliminary findings that lead to larger future studies. Consistent with the title, clinical trials are not allowed under this opportunity, meaning applicants should not propose prospective assignment of participants to interventions or conditions. The emphasis is on analyzing existing, already-collected ABCD data and producing insights that advance child and adolescent health research.
Eligibility is intentionally broad to attract a wide range of institutions and perspectives. Eligible applicants include multiple levels of government (state, county, city/township, and special districts), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, and a variety of nonprofit and for-profit organizations (including small businesses). Tribal entities are also included, both federally recognized tribal governments and other tribal organizations. The announcement explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, non-U.S. (foreign) organizations, regional organizations, and U.S. territories or possessions. This breadth signals a strong interest in diversifying the applicant pool and encouraging research that reflects different communities, disciplines, and analytic traditions.
From an administrative standpoint, the opportunity is categorized as a discretionary grant under NIH, with activity areas spanning environment and health, and it lists CFDA numbers 93.113, 93.242, 93.273, and 93.313. The original closing date provided is 2025-05-07, and the FOA was created on 2022-03-15. While the excerpt does not specify an award ceiling or expected number of awards, the defining feature is the targeted use of ABCD public-use data and the expectation that proposed work will meaningfully expand understanding of adolescent health and development using that shared national resource. For additional context about the underlying dataset and study design, NIH points applicants to the ABCD Study website at www.abcdstudy.org.Apply for PAR 22 138
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R21-Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.242, 93.273, 93.313.
- This funding opportunity was created on 2022-03-15.
- Applicants must submit their applications by 2025-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Hazardous Materials Worker Health and Safety Training (U45 Clinical Trials Not Allowed) Apply for RFA ES 24 001 Funding Number: RFA ES 24 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 24 003 Funding Number: RFA ES 24 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
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| CCRP Initiative: Chemical Threat Agent-induced Pulmonary and Ocular Pathophysiological Mechanisms (R01 Clinical Trial Not Allowed) Apply for RFA ES 24 005 Funding Number: RFA ES 24 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
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